(#Co-first Author, ※Correspondence Author)

2023年

　　　F. Nakamura, Y. Shimba, S. Toyonaga, C. Kuroda, A. Yamato, Y. Yamada, T. Hosaka※: Delayed dinnertime impairs glucose tolerance in healthy young adults. Journal of Diabetes Investigation, in press.

           Kim CLT, Xuan DD, Dang VN, Duc HL, Minh HBT, Thi HL, Huu TN,Tran NL, Hosaka T and Thu TNT. Insulin signal and it’s application. Frontier in Endocrinology just accepted 2023

            Shichijo H, Hosaka T※, Takewaki F, Sumitani Y, Ishida H, Yasuda K. Post-meal endogenous insulin secretion was significantly lower in head than in body/tail cancer of the pancreas. Journal of Medical Investigation 70 350-354 2023

　　　Y. Iwayama, Y. Shimba#※, C. S. Viswanathan, Y. Yano: Effect and factors associated with weight and waist circumference reductions in information and communication technology-based specific health guidance. Environ Occup Health Practice. 5: eohp.2023-0001-OA (2023).

　　　Y. Shimba, R. Suzumura, H. Nakatogawa, T. Watanabe: Nutritional intervention improves prognosis of subarachnoid hemorrhage patients undergoing aneurysmal clipping: a retrospective study. Journal of Medical Investigation 70:226-230 (2023).

2022年

        Kawakami Y, Mazuka M, Yasuda A, Sato M, Hosaka T,  Arai H.  Acute effect of fructose, sucrose, and isomaltulose on uric acid metabolism in healthy participants. Journal of Clinical Biochemistry and Nutrition 72 (1) 61-67 2023.

　　Yamada K, Hyodo T, Urabe S, Haga S, Hosaka T# : Serum YKL-40 Levels as an Inflammation Marker are Associated with Malnutrition and Atherosclerosis in Patients on Hemodialysis. Journal of Medical Investigation 69 (1,2) 101～106 2022

2021年

　　Y. Kawakami, A. Yasuda, M. Hayashi, M. Akiyama, T. Asai, T. Hosaka, H. Arai. : Acute effect of green tea catechins on uric acid metabolism after alcohol ingestion in Japnanese men. Clinical Reumatology 2021 Feb 

　　Y. Shimba, R. Senda, K. Katayama, A. Morita, M. Ikeda, Y. Kamei, S. Miura: Skeletal muscle-specific forkhead box protein-O1 overexpression suppresses atherosclerosis progression in apolipoprotein E-knockout mice. Biol. Biophys. Res. Commun., 540 (1): 61-66 (2021). 

2020年

　　Takahashi R, Yoshida T, Toku H, Otsuki N, and Hosaka T : Impact of meal timing on postprandial interstitial fluid glucose levels in young Japanese females. J Nutr Sci Vitaminol. 2020 Dec 6;66: 593-596　

 　　Y. Shimba, K. Katayama, N. Miyoshi, M. Ikeda, A. Morita, S. Miura: β-aminoisobutyric acid suppresses atherosclerosis in apolipoprotein E-knockout mice. Biological and Pharmaceutical Bulletin, 43 (6): 1016-1019 (2020).

2019年

　　Morita N, Hoaska T, Yamazaki Y , Takahashi K, Sasano H, Ishida H.  Abnormal glucose intolerance in a patient with pheochromocytoma and ACTH-independent subclinical Cushing’s syndrome involving the same adrenal J Int Med Res. 2019 Jul;47(7):3360-3370.

　　Ishitobi M, Hosaka T※, Morita N, Kondo K, Murashima T, Kitahara A, Takahashi K, Sumitani Y, Tanaka T, Yokoyama T, Kondo T, Ishida : Serum lactate levels are associated with serum alanine aminotransferase and total bilirubin levels in patients with type 2 diabetes mellitus: A cross-sectional study. Diabetes Res Clin Pract. 2019 Jan 31;149:1-8.

　　Y. Shimba, H. Togawa, N. Senoo, M. Ikeda, N. Miyoshi, A. Morita, S. Miura: Skeletal muscle-specific PGC-1α overexpression suppresses atherosclerosis in apolipoprotein E-knockout mice. Scientific Reports, 9: 4077 (2019).

　　S. Onishi, S. Meguro, M. Pervin, H. Kitazawa, A. Yoto, M. Ishino, Y. Shimba, Y. Mochizuki, S. Miura, I. Tokimitsu, K. Unno: Green tea extracts attenuate brain dysfunction in high-fat diet-fed SAMP8 mice. Nutrients, 11 (4): 821 (2019).

2018年

　　Ito S, Hosaka T※, Yano W, Itou T, Yasumura M, Shimizu Y, Kobayashi H, Nakagawa T, Inoue K, Tanabe S, Kondo T, Ishida H : Metabolic Effects of Tofogliflozin are Efficiently Enhanced with Appropriate Dietary Carbohydrate Ratio and are Distinct from Carbohydrate Restriction.Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13642.

　　Morita N, Hosaka T, Kitahara A, MurashimaT, Onuma H, Sumitani Y, Takahashi K, Tanaka T, Kondo T, Ishida H : Novel mechanisms modulating palmitate-induced inflammatory factors in hypertrophied 3T3-L1 adipocytes by AMPK. J Diabetes Res. 2018 Mar 11;2018:9256482. 

　　S. Onishi, M. Ishino, H. Kitazawa, A. Yoto, Y. Shimba, Y. Mochizuki, K. Unno, S. Meguro, I. Tokimitsu, S. Miura: Green tea extracts ameliorate high-fat diet-induced muscle atrophy in senescence-accelerated mouse prone-8 mice. PLoS ONE, 13(4): e0195753 (2018).

2017年

　　Kitahara A, Takahashi K, Morita N, Murashima T, Ounuma H, Sumitani Y, Tanaka T, Kondou T, Hosaka T, Ishida H : The novel mechanisms concerning the inhibitions of palmitate-induced proinflammatory factor releases and endogenous celluler stresses with astaxanthin on MIN6 β cells.Mar Drugs. 2017 Jun 20;15(6). pii: E185. 

2016年

　　Sumitani Y, Hosaka T, Susaki Y, Fujisawa Y, Kuriyama K, Tsukada Y, Yokoyama T, Ogasawara J, Nishida S, Inukai K, Okajima Y, Ohno H, Ishida H : Clinical effect of real time pulse rate monitoring with portable pulsimeter on physical exercise therapy for male patients with type 2 diabetes. Diabetology International 7(3):228-234 2016

2015年

　　Katsuta H, Ozawa S, Suzuki K, Takahashi K, Tanaka T, Sumitani Y, Nishida S, Kondo T, Hosaka T, Inukai K, Ishida H: The association between impaired proinsulin processing and type 2 diabetes mellitus in non-obese Japanese individuals. Endocr J. 62(6):485-492, 2015

　　Iuchi T, Hosaka T※, Shiroishi M, Ono H, Inukai K, Sumita T, Sakai G, Katayama S, Awata T: Influence of treatment with extracts of Hypsyzigus marmoreus mushroom on body composition during obesity development in KK-Ay mice. J Nutr Sci Vitaminol (Tokyo) 61(1) 96-100, 2015. 

　　Le TKC, Hosaka T, Trung NT, Kassu A, Oanh DT, Ba TH, Phuong PT, QuangBinh T :  Bifidobacterium species lower serum glucose, increase insulin signaling protein expressions and improve adipokine profile in diabetic mice.. BIOMEDICAL RESEARCH 36(1) 63-70, 2015.

2014年

　　Onuma H, Inukai K, Kitahara A, Moriya R, Nishida S, Tanaka T, Katsuta H, Takahashi K, Sumitani Y, Hosaka T, Ishida H: The glucagon-like peptide 1 receptor agonist enhances intrinsic peroxisome proliferator-activated receptor g activity in endothelial cells. Biochem Biophys Res Commun 451 339–344 2014.

　　Handa K, Inukai K, Onuma H, Kudo A, Nakagawa F, Tsugawa K, Kitahara A, Moriya R, Takahashi K, Sumitani Y, Hosaka T, Kawakami H, Oyadomari S, Ishida H : Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice. PLoS One. 9(8) e104948 2014. 

　　Le TKC, Hosaka T, Le TTT, Nguyen TG, Tran QB, Le THH, Pham XD: Oral administration of Bifidobacterium spp. improves insulin resistance, induces adiponectin and prevents inflammatory adipokine expressions. Biomed Res. 35(5) 303～10 2014.

　　Inukai K, Hirata T, Sumita T, Watanabe M, Ikegami Y, Ito D, Kurihara S, Yasukawa N, Morimoto J, Takata N, Kanazawa K, Neda T, Sumitani Y, Inoue K, Noguchi Y, Hosaka T, Ishida H, Katayama S : Clinical Characteristics of Japanese Type 2Diabetic Patients Responsive to Sitagliptin. Journal of Diabetes Mellitus, 4, 172～178 2014.

　　Tsutsumi R, Yoshida T, Nii Y, Okahisa N, Iwata S, Tsukayama M, Hashimoto R, Taniguchi Y, Sakaue H, Hosaka T, Shuto E, Sakai T: Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle. Nutrition & Metabolism (Lond). 11(32) eCollection 2014.

　　Hosaka T※, Sasaga S, Yamasaka Y, Nii Y, Edazawa K, Tsutsumi R, Shuto E, Okahisa N, Iwata S, Tomotake H, Sakai T : Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-Ay mice. The journal of medical investigation 61(3,4) 345～52 2014

　　Onuma H, Inukai1 K, Watanabe M, Sumitani Y, Hosaka T, Ishida H: Effects of long-term monotherapy with glimepiride vs glibenclamide on glycemic control and macrovascular events in Japanese Type 2 diabetic patients. Journal of Diabetes Mellitus 4(1) 33～37 2014

2013年

　　Jambaldorj B, Hosaka T#※, Terada E, Kishuku Y, Tomioka Y, Iwashima K, Hirata Y, Teshigawara K, Le CTK, Nakagawa T, Harada N, Sakai T, Sakaue H, Matsumoto T, Funaki M, Takahashi A, Nakaya Y: CSP1 modulates insulin sensitivity by attenuating GLUT4 vesicle docking with the plasma membrane.  The journal of medical investigation 60 (3,4) 197～204 2013

　　Li Q, Hosaka T, Harada N, Nakaya Y, Funaki M: Activation of Akt through 5-HT2A receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 in adipocytes. Mol Cell Endocrinol. 365(1):25～35 2013

2012年

　　Hosaka T※, Nii Y, Tomotake H, Ito T, Tamanaha A, Yamasaka Y, Sasaga S, Edazawa K, Tsutsumi R, Shuto E, Okahisa N, Iwata S, Sakai T: Extracts of common buckwheat bran prevent sucrose digestion. J Nutr Sci Vitaminol (Tokyo). 57(6) 441～445 2012

　　Sakai T, Shuto E, Taki T, Imamura H, Kioka M, Nakamoto A, Mizoguchi S, Amano S, Kawano Y, Nakamoto M, Tsutsumi R, Hosaka T: Decreased expression of MHC class II and cathepsin E in dendric cells might contribute to impaired induction of antigen-specific T cell response in NC/Nga mice. The journal of medical investigation 59(1-2) 95～101 2012

　　Neda T, Inukai K, Kurihara S, Ono H, Hosaka T, Nakamoto H, Katayama S, Awata T.: Hypoglycemic effects of colestimide on type 2 diabetic patients with obesity. Endocr J. 59(3) 239～246 2012

　　Li Q, Hosaka T, Shikama Y, Bando Y, Kosugi C, Kataoka N, Nakaya Y, Funaki M: Heparin-binding EGF-like growth factor (HB-EGF) mediates 5-HT-induced insulin resistance through activation of EGF receptor-ERK1/2-mTOR pathway. Endocrinology 153(1) 56～68 2012.

　　Tsutsumi R, Tsutsumi Y, Horikawa Y, Takehisa Y, Hosaka T, Harada N, Sakai T, Nakaya Y: Decline in anthropometric evaluation predicts a poor prognosis in geriatric patients. Asia Pac J Clin Nutr. 21(1) 44～51 2012

2011年

　　Sakai T, Furoku S, Nakamoto M, Shuto E, Hosaka T, Nishioka Y, Sone S: Soy Isoflavone Equol Perpetuates Dextran Sulfate Sodium-Induced Acute Colitis in Mice. Biosci Biotechnol Biochem 75(3) 593～5 2011

　　Sakai T, Hirota Y, Nakamoto M, Shuto E, Hosaka T, Makino S, Ikegami S: Suppression of Oral Tolerance by Lactococcus lactis in Mice. Biosci Biotechnol Biochem  75(3) 599～601 2011

　　Nakamoto M, Shuto E, Hosaka T, SakaiT: Dietary deoxynucleic acid induces type 2 T-helper immune response through toll-like receptor 9 in mice. European Journal of Nutrition 50(6) 421～6 2011

　　Hirata Y, Hosaka T#※, Iwata T, Le CTK, Jambaldorj B, Teshigawara K, Harada N, Sakaue H, Sakai T, Yoshimoto K Nakaya Y: Vimentin binds IRAP and is involved in GLUT4 vesicle trafficking. Biochem Biophys Res Commun 405(1) 96～101 2011

2010年

　　Teshigawara K, Hosaka T#※, Yamaguchi M, Terada E, kisyuku Y, Fukunaga K, Hirata Y, Jambaldorj B, Harada N, Sakai T, Nakaya Y : Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice. The journal of medical investigation 57(3,4)  224～231 2010

　　Le CTK, Hosaka T#, Harada N,Jambaldorj B Fukunaga K Nishiwaki Y, Teshigawara K, Sakai T, Nakaya Y, Funaki M, Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-L1 adipocytes  Biochem Biophys Res Commun 391(1) 995～999 2010

　　Sakai T, Furoku S, Nakamoto M, Shuto E, Hosaka T, Nishioka Y, Sone S : The soy isof lavone equol enhances antigen-specific IgE productionin ovalbumin- immunized BALB/c mice. J.Nutr.Sci.Vitaminol. 56, 72～76, 2010

2009年　

　　Le TKC, Hosaka T#※, Yoshida M, Harada N, Sakaue H, Sakai T, Nakaya Y : Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression. Biochem Biophys Res Commun 390(3) 613～618 2009

　　Li Q, Hosaka T, Jambaldorji B, Nakaya Y and Funaki M : Extracelluar matrix with the rigidity of adipose tissue helps 3T3-L1 adipocytes maintain insulin responsiveness. The journal of medical investigation 56(3,4): 142～149 2009

　　Yuasa T, Uchiyama K, Ogura Y, Kimura M, Teshigawara K, Hosaka T, Tanaka Y, Obata T, Sano H, Kishi K, Ebina Y : The Rab GTPase-activating protein AS160 as a common regulator of insulin- and Gaq-mediated intracellular GLUT4 vesicle distribution. Endocr J. 56(3):345～59 2009

　　Yoshida M, Harada N, Yamamoto H, Taketani Y, Nakagawa T, Yin Y, Hattori A, Zenitani T, Hara S, Yonemoto H, Nakamura A, Nakano M, Mawatari K, Teshigawara K, Arai H, Hosaka T, Takahashi A, Yoshimoto K, Nakaya Y: Identification of cis-acting promoter sequences required for expression of theglycerol-3-phosphate acyltransferase 1 gene in mice. BBA（Molecular and Cell Biology of Lipids）1791(1):39～52 2009

2023年

金澤千聖、榛葉有希、黒田千恵実、豊永咲、浅井寿彦、保坂利男：2型糖尿病患者の栄養食事指導における満足度と食事療法継続要因の検討、病態栄養、印刷中

保坂利男（企画編集）：食と糖尿病・糖代謝、肥満との関係、月刊糖尿病 15(5) 2023

榛葉有希：情報通信技術を活用した食事指導～オンライン指導とアプリケーションの利用～、月刊糖尿病 15(5)71-78 2023.

2022年

豊永咲、保坂利男：糖尿病と微量元素：月刊さかえ 62 (8) 35-38 2022

2018年

金城真美、竹脇史絵、石飛実紀、保坂利男、石田均、奴田原紀久雄 糖尿病と下部尿路症状 糖尿病合併症32(1) 70-73 2018

保坂利男：健康補助食品と糖尿病：プラックティス. 35(4)426-428 2018

保坂利男、石田均：そもそも「エネルギー」とは何のこと？、食べたものはすべてエネルギーになるの？：糖尿病ケア.15(9)770-771 2018

保坂利男、石田均：炭水化物はすべてエネルギーになるの？どのように消費されてエネルギーになるの？：糖尿病ケア.15(9)772-773 2018

保坂利男：4章 病態や合併症に応じた糖尿病治療薬の選択；7肥満のある場合：jmed 57 あなたも名医！スキルアップを目指す糖尿病治療薬 137-141 2018

　保坂利男：微量元素と糖尿病：プラックティス. 35(5)553-555 2018

　保坂利男：糖尿病における栄養配分と質：プラックティス. 35(6)684-687 2018